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ECMC Trial Portfolio

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All Solid Tumours

Project Title Website PI Recruitment Contact


A Phase I trial of oral CCT245737 (a CHK1 inhibitor) given in combination with gemcitabine plus cisplatin or gemcitabine alone in patients with advanced cancer


A Phase I trial of oral CCT245737 Prof D Palmer 0 Send E-mail


A Phase I trial of SRA737 (a CHK1 inhibitor) administered orally in subjects with advanced cancer


SRA737-01 Prof D Palmer 0 Send E-mail


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All Solid Tumours & Lymphomas

Project Title Website PI Recruitment Contact


An Open-Label, Single Center, Two-Part, Phase 1 Study to Characterize the Pharmacokinetics of a Single Intravenous Micro-Dose of Tazemetostat (EPZ-6438) and the Absorption, Distribution, Metabolism and Elimination of a Single Oral [C] Labelled Dose of Tazemetostat in Subjects with Advanced Solid Tumours or With Lymphomas


EPZ-6438: IV microtracer and ADME Study Prof D Palmer 3 Send E-mail


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Project Title Website PI Recruitment Contact


A randomized phase IB/IIA study of CApecitabine plus Radium-223 (Xofigo) in breast cancer patients with BONe metastases (CARBON): an open-label interventional study


CARBON Prof C Palmieri 7 Send E-mail


A multiple parallel cohort, non-randomised, open label, multi-centre phase IIa clinical trial aiming to provide proof of principle efficacy for designated targeted therapies in patients with advanced breast cancer where the targetable mutation is identified through ctDNA screening


plasmaMATCH Prof C Palmieri 3 Send E-mail


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Project Title Website PI Recruitment Contact


An Open-Label Phase 1B Study Of Pf 04449913 (Glasdegib) In Combination With Azacitidine In Patients With Previously Untreated Higher Risk Myelodysplastic Syndrome, Acute Myeloid Leukemia , Or Chronic Myelomonocytic Leukemia


A Combination Study Of Pf-04449913 And Azacitidine In 1St Line Mds, Aml And Cmml Patients Pending Pending Send E-mail


AVAIL-T: A Phase 2a trial of Avelumab, an anti-PDL1 antibody, in relapsed and refractory peripheral T-cell lymphoma (PTCL)


AVAIL-T Dr. A. Arumainathan 1 Send E-mail


GO29834: A Phase Ib/II Study Evaluating the Safety and Efficacy of Obinutuzumab in Combination with Polatuzumab Vedotin and Lenalidomide in Patients with Relapsed or Refractory Follicular or Refractory Follicular or Diffuse Large B-Cell Lymphoma


GO29834 Dr. A. Arumainathan Pending Send E-mail


Matchpoint: Management of Transformed Chronic myeloid leukaemia: Ponatinib and Intensive chemotherapy: a dose finding trial


Matchpoint Dr. R. Clark Pending Send E-mail


PHAZAR: A phase Ib study to assess the safety and tolerability of oral Ruxolitinib in combination with 5-azacitidine in patients with advanced phase myeloproliferative neoplasms (MPN), including myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML) arising from MPN.


PHAZAR Dr. R. Salim 0 Send E-mail


RomiCar - Phase I/II study to determine the maximum tolerated dose and overall response rate of the combination of romidepsin and carfilzomib in relapsed or refractory peripheral T-cell lymphoma


RomiCAR Dr. N . Kalakonda 0 Send E-mail


TAMARIN: Effects of Tamoxifen on the Mutant Allele Burden and Disease Course in Patients with Myeloproliferative Neoplasms


TAMARIN Pending 2 Send E-mail


Risk-stratified sequential Treatment with Ibrutinib and Rituximab (IR) and IR-CHOP for De-novo post-transplant Lymphoproliferative disorder (PTLD)


TIDaL Dr A. Arumainathan 2 Send E-mail


UK HAPLO: A UK multicentre phase II study of haploidentical stem cell transplantation in patients with haematological


UK HAPLO Dr. R. Salim Pending Send E-mail


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Head & Neck

Project Title Website PI Recruitment Contact


Cambridge Brain Mets Trial 1: A proof­ of principle phase 1b / randomised phase 2 study of afatinib penetration into cerebral metastases for patients undergoing neurosurgical resection, both with and without prior low­-dose, targeted radiotherapy


CamBMT1 Dr B Haylock 0 Send E-mail


An Open-Label, Multicenter, Phase 1/2 Study of RPI as a Single Agent and in Combination with Immune Checkpoint Blockade or Other Standard of Care Regimens in Patients with Solid Tumors


REPLIMUNE Dr J Sacco 2 Send E-mail


A Phase I trial of WEE1 inhibition with Chemotherapy and Radiotherapy as adjuvant treatment, and a Window of Opportunity trial with Cisplatin in Patients with Head and Neck Cancer


WISTERIA: WEE1 inhibitor with Cisplatin and Radiotherapy Dr J Sacco 0 Send E-mail


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HPB / Upper GI

Project Title Website PI Recruitment Contact


ACIT I: A Phase I clinical study to determine the optimal dose for the safe immune restoration and immune response of allogeneic cell immunotherapy (ACIT-1) in adult cancer patients


ACIT-1 Prof. Palmer 18 Send E-mail


BLU 554: A Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of BLU-554 in Patients with Hepatocellular Carcinoma and Cholangiocarcinoma


BLU-554 / CANC 4809 Prof. Daniel Palmer 1 Send E-mail


A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects With Advanced/Metastatic or Surgically Unresectable Cholangiocarcinoma Including FGFR2 Translocations Who Failed Previous Therapy


FIGHT-202 Prof. Daniel Palmer 7 Send E-mail


A Phase II Study of Pembrolizumab (MK-3475) as Monotherapy in Subjects with Previously Systemically Treated Advanced Hepatocellular Carcinoma (KEYNOTE-224)


KEYNOTE-224 Prof. Daniel Palmer 5 Send E-mail


OUTREACH: A First-in-Human, multi-centre, open-label, Phase 1 clinical study with RNA oligonucleotide drug MTL-CEBPA to investigate its safety and tolerability in patients with advanced liver cancer (OUTREACH)


OUTREACH / CANC 4818 Prof. Daniel Palmer 1 Send E-mail


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Project Title Website PI Recruitment Contact


The Cancer Research UK Stratified Medicine Programme: Pilot Study


CR UK Stratified Medicine Pilot study Dr. Carles Escriu 22 Send E-mail


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Project Title Website PI Recruitment Contact


EORTC Soft Tissue and Bone Sarcoma Group: Randomized phase II trial of cabazitaxel or prolonged infusional ifosfamide in metastatic or inoperable locally advanced dedifferentiated liposarcoma


EORTC-1202-STBSG Dr. Ali 1 Send E-mail


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