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ECMC Trial Portfolio

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All Solid Tumours

Project Title Website PI Recruitment Contact

 

A Phase 1 Study to Investigate the Absorption, Metabolism, and Excretion of [14C] Pamiparib following Single Oral Dose Administration in Patients with Advanced and/or Metastatic Solid Tumors

 

Disposition of[14C]Pamiparib in Patients with Tumours Prof D Palmer 3 Send E-mail

 

An Open-Label, Multicenter, Phase 1/2 Study of RP1 as a Single Agent and in Combination with Immune Checkpoint Blockade or Other Standard of Care Regimens in Patients with Solid Tumors

 

REPLIMUNE Dr J Sacco 4 Send E-mail
  7  

 

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Breast

Project Title Website PI Recruitment Contact

 

A multiple parallel cohort, non-randomised, open label, multi-centre phase IIa clinical trial aiming to provide proof of principle efficacy for designated targeted therapies in patients with advanced breast cancer where the targetable mutation is identified through ctDNA screening

 

plasmaMATCH Prof C Palmieri 7 Send E-mail
  7  

 

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Haematology

Project Title Website PI Recruitment Contact

 

AVAIL-T: A Phase 2a trial of Avelumab, an anti-PDL1 antibody, in relapsed and refractory peripheral T-cell lymphoma (PTCL)

 

AVAIL-T Dr. A. Arumainathan 1 Send E-mail

 

Treatment of steroid refractory gastro-intestinal acute graft-versus-Host disEase afteR AllogeneiC hematopoietic stem celL transplantation with faEcal microbiota transfer (HERACLES)

 

HERACLES Dr. A. Patel 0 Send E-mail

 

A phase Ib study to assess the safety and tolerability of oral Ruxolitinib in combination with 5-azacitidine in patients with advanced phase myeloproliferative neoplasms (MPN), including myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML) arising from MPN.

 

PHAZAR Dr. A. Patel 1 Send E-mail

 

RomiCar - Phase I/II study to determine the maximum tolerated dose and overall response rate of the combination of romidepsin and carfilzomib in relapsed or refractory peripheral T-cell lymphoma

 

RomiCAR Dr. N . Kalakonda 1 Send E-mail

 

Risk-stratified sequential Treatment with Ibrutinib and Rituximab (IR) and IR-CHOP for De-novo post-transplant Lymphoproliferative disorder (PTLD)

 

TIDaL Dr A. Arumainathan 2 Send E-mail
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Head & Neck

Project Title Website PI Recruitment Contact

 

Cambridge Brain Mets Trial 1: A proof­ of principle phase 1b / randomised phase 2 study of afatinib penetration into cerebral metastases for patients undergoing neurosurgical resection, both with and without prior low­-dose, targeted radiotherapy

 

CamBMT1 Dr B Haylock 0 Send E-mail

 

NICO - CA209-891: Neoadjuvant and adjuvant nivolumab as Immune Checkpoint inhibition in Oral cavity cancer

 

NICO Dr A Haridass 0 Send E-mail

 

A Phase I trial of WEE1 inhibition with Chemotherapy and Radiotherapy as adjuvant treatment, and a Window of Opportunity trial with Cisplatin in Patients with Head and Neck Cancer

 

WISTERIA: WEE1 inhibitor with Cisplatin and Radiotherapy Dr J Sacco 1 Send E-mail
  1

 

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HPB / Upper GI

Project Title Website PI Recruitment Contact

 

ACIT I: A Phase I clinical study to determine the optimal dose for the safe immune restoration and immune response of allogeneic cell immunotherapy (ACIT-1) in adult cancer patients

 

ACIT-1 Prof. D Palmer 23 Send E-mail

 

OUTREACH: A First-in-Human, multi-centre, open-label, Phase 1 clinical study with RNA oligonucleotide drug MTL-CEBPA to investigate its safety and tolerability in patients with advanced liver cancer (OUTREACH)

 

OUTREACH / CANC 4818 Prof. D Palmer 5 Send E-mail

 

Phase 1-2 Study of ADI-PEG 20 plus FOLFOX in Subjects with Advanced Gastrointestinal Malignancies Focusing on Hepatocellular Carcinoma

 

Phase 1-2 Study of ADI plus FOLFOX in GI cancer focusing on HCC Prof. D Palmer 0 Send E-mail
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Lung

Project Title Website PI Recruitment Contact

 

The Cancer Research UK Stratified Medicine Programme: Pilot Study

 

CR UK Stratified Medicine Pilot study Dr. Carles Escriu 59 Send E-mail
  59  

 

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Melanoma

Project Title Website PI Recruitment Contact

 

A parallel arm, biomarker driven, phase II feasibility trial to determine the role of circulating tumour DNA in guiding a switch between targeted therapy and immune therapy in patients with advanced cutaneous melanoma

 

Circulating tumour DNA guided therapy switch (CAcTUS) Dr. Shien Chow 0 Send E-mail
  0  

 

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