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Clinical Trials

The LCTU has a number of current trials as well as trials that have now closed. There are also several trials that are under development. Please click on a Trial Group or Trial Title for more information


Breast

CiPHER Phase II multicentre study assessing the efficacy of Cabazitaxel in Patients with HER2-negative metastatic breast cancer and having unresectable brain metastases
Margin Probe Margin Probe
TIP Thrombin Inhibition Preoperatively in Early Breast Cancer

Diabetes

ENERGIZE Compensatory changes in energy balance during dapagliflozin treatment in type 2 diabetes
RESILIENT RandomisEd, controlled, double blind Study to assess mechanistic effects of combination therapy of dapagliflozin with Exenatide QW versus dapagliflozin alone in obese (BMI>30 kg/m2) patients with Type 2 diabetes mellitus.
ROMANCE A randomised, controlled mutli-centre trial of 26 weeks of subcutaneous Liraglutide (a GLP-1 receptor agonist), with or without continious positive airway pressure (CPAP) in patients with type 2 Diabetes Mellitus (T2DM) and Obstructive Sleep Apnoes (OSA)

Haematology

CLL210 Phase II trial of ofatumumab, dexamethasone and lenalidomide for high-risk CLL (NCRI CLL210)
DESTINY A trial of de-escalation and stopping treatment in chronic myeloid leukaemia patients with excellent responses to tyrosine kinase inhibitor therapy (De-Escalation and Stopping Treatment of Imatinib, Nilotinib or sprYcel in chronic myeloid leukaemia)
PACIFICO Purine-Alkylator Combination In Follicular lymphoma Immuno-Chemotherapy for Older patients
RIAltO RIAltO: A Randomised Investigation of Alternative Ofatumumab-containing regimens in less fit patients with CLL
UK CLL Trials Biobank UK CLL Trials Biobank

Head and Neck

DAHANCA-21 Hyperbaric oxygen treatment of mandibular osteoradionecrosis.
HOPON HOPON: Hyperbaric Oxygen for the Prevention of Osteoradionecrosis.
REALISTIC A Phase I, Dose Escalation Trial Of Recombinant Listeria Monocytogenes (Lm)-Based Vaccine Encoding Human Papilloma Virus Serotype 16 Target Antigens (ADXS11-001) In Patients With HPV-16 +ve Oropharyngeal Carcinoma
SAVER Sodium Valproate for Epigenetic Re-programming in Management of High Risk Oral Epithelial Dysplasia
TITAN Trial of Induction TPF Therapy in Advanced Head & Neck Cancer.

Hepatobilary

ACIT-1 A Phase I clinical study to determine the optimal dose for the safe immune restoration and immune response of allogeneic cell immunotherapy (ACIT-1) in adult cancer patients
BBC-01 BBC01- BBC: Phase II study of neoadjuvant cisplatin and gemcitabine chemotherapy versus upfront surgery in patients with locally advanced / borderline resectable proximal biliary tract cancer:

Lung

UKLS UK Lung Cancer Screening Trial

Melanoma

ITEM ITEM: A Phase II Study of Imatinib in the Treatment of Patients with Metastatic Uveal Melanoma
NITRO Neo-adjuvant IntraviTreal Ranibizumab treatment in high risk Ocular melanoma patients: A two stage single centre Phase II single arm study.
SelPac A Randomised three-arm, open label, Phase II study of continuous Selumetinib versus continuous or interrupted Selumetinib in combination with weekly Paclitaxel in Metastatic Uveal Melanoma.
SUAVE A randomised phase II study of Sunitinib versus Dacarbazine in the treatment of patients with metastatic uveal melanoma ** Recruitment is on-hold as of 08 November 2012

Other

APPA APPA
APRiCOT A Pilot Randomised Study to Compare Combination Antibiotic Therapy (Ciprofloxacin, Doxycycline and Hydroxychloroquine) with Standard Therapy (Budesonide) in the Treatment of Active Crohn's Disease
BEA Multifrequency Bioimpedance in the Early Detection of Lymphoedema after Axillary Surgery
BIOBehcets Optimal utilisation of biologic drugs in Behçet's Disease: a randomised controlled trial of infliximab vs alpha interferon, with genotyping and metabolomic profiling, towards a stratified medicines approach to treatment.
BIOPROP BIOPROP
CHAMPion Cancer-induced Hypercoagulability as a marker of prognosis
CIMI DENT A pilot randomised controlled trial of coventional implants vs mini implants used to retain full lower dentures
COMICE Randomised Trial of Ceriranib and Olaparib Maintenance in patients with Advanced/recurrent Cervical Cancer
MERCK PN114 MERCK PN114
PIVOTAL PIVOTAL: Pharmacological Individualisation of VOriconazole Therapy for AntifungaL treatment
PLACE Prevention of Lymphoedema after Clearance by External Compression (PLACE)
RECAP A Three arm Randomized Controlled Trial of Progesterone, Arabin Pessary and Cervical Cerclage to prevent Spontaneous Preterm Birth in an Asymptomatic High Risk Cohort with Short Cervix (RECAP)
STRIDER A Randomised Controlled Trial of Sildenafil Therapy In Dismal Prognosis Early Onset intrauterine Growth Restriction.

Palliative Care

BIVA Hydration in palliative cancer patients: the testing of a new assessment method
ChemdEL Chemical compatibility of drug combinations used in end of life care.
CODV A Living Community Presence – Evaluation of an innovative approach for volunteers to support the care of patients and their families in the last hours and days of life.
Demoralisation A prospective longitudinal study to determine the prevalence, aetiology and natural history of depression and demoralisation in patients with advanced metastatic cancer
INPIC Invasive Procedures In Cancer Pain
LCPC Care of the Dying Child: development, implementation and evaluation of the Liverpool Care Pathway for the Dying Child

Pancreas

ACELARATE A Phase III, open label, multicentre randomized clinical trial comparing Acelarin (NUC-1031) with Gemcitabine in patient with metastatic pancreatic carcinoma
ESPAC-1 European Study Group for Pancreatic Cancer Trial 1 - Adjuvant Therapy in Operable Pancreatic Cancer
ESPAC-3 / ESPAC-3(v2) European Study Group for Pancreatic Cancer (ESPAC) - Trial 3. Adjuvant Chemotherapies in Resectable Pancreatic Cancer
ESPAC-4 EUROPEAN STUDY GROUP FOR PANCREATIC CANCER (ESPAC) - Trial 4. Combination versus single agent chemotherapy in resectable pancreatic ductal and peri-ampullary cancers.
ESPAC-5F EUROPEAN STUDY GROUP FOR PANCREATIC CANCER - TRIAL 5F Four arm, prospective, multicentre, randomised feasibility trial of immediate surgery compared with neoadjuvant chemotherapies and neoadjuvant chemoradiotherapy.
EUROPAC2 European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC)2 trial to investigate the efficacy of antioxidants and magnesium for the treatment of Hereditary Pancreatitis and Idiopathic Chronic Pancreatitis.
GEMCAP A phase III multicentre randomised clinical trial comparing gemcitabine alone or in combination with capecitabine for the treatment of patients with advanced pancreatic cancer.
PANASTA Cattell Warren versus Blumgart techniques of pancreatico-jejunostomy following pacreato-duodenectomy – a double blinded multi-centred trial (Phase III).
PETPANC The Impact of combined modality positron emission tomography with computerised tomography scanning (PET/CT) in the diagnosis and management of pancreatic cancer.
TeloVac A prospective, phase III, controlled, multicentre, randomised clinical trial comparing combination gemcitabine and capecitabine therapy with concurrent and sequential chemoimmunotherapy using a telomerase vaccine in locally advanced and metastatic pancrea
VIP A prospective, phase II, double blinded, multicentre, randomised clinical trial comparing combination gemcitabine and Vandetanib therapy with gemcitabine therapy alone in locally advanced or metastatic pancreatic carcinoma

Translational

ESPAC-Tplus A Translational Study, Characterisation of Tumour Molecular Response Predictors of Chemotherapy and Radiotherapy Treatments for Pancreatic Cancer in Patients in the ESPAC Trials

Urology

BIOPROP20 Biologically optimised IMRT for Prostate Radiotherapy. Hypofractionated radiotherapy with intra-prostatic boosts to tumour nodules in men with intermediate and high risk prostate cancer
NEOBLADE Phase II randomised placebo controlled Neoadjuvant chemotherapy study of Nintedanib with Gemcitabine and Cisplatin in locally advanced muscle invasive bladder cancer

All recruitment and site information is updated hourly from LCTU systems