Liverpool Good Clinical Practice Laboratories

Established in 2009, the Good Clinical Practice Laboratory Facility (GCPLab) has extensive experience of acquiring, storing and analysing high quality human biological samples linked to anonymised clinical trials.

The GCPLab aims to produce transparent, reliable, reproducible results, whilst also giving traceability, auditability and accountability. The GCPLab works to defined quality standards, incorporating regulatory requirements which govern translational research.

Good Clinical Practice Laboratory Equipment

Freezers and fridges (9x −80°C freezers, 6x −150°C freezers, 3x −20°C freezers, 1x −30°C freezer and 2x large 4°C fridges). All temperatures are monitored with independent probes attached to the Pharmagraph Environmental Monitoring System. The total storage space exceeds 600,000 1.5 ml tubes.
Customised Matrix Laboratory Information Management System with individual trial workflows - hierarchical and fully auditable.
Immunomonitoring: Plate reader and washer, Luminex, reader/imager, beta counter, Tomtec cell harvester.
Cytometry: FACSCanto/FACSFortesa, centrifuges, nucleocounter.
Molecular biology and histology: PCR machines (including light cycler and biorad), Prokyma bead separation, Maxwell rapid sample concentrator robot, OneTouch, Ion torrent next generation sequencer, TMA arrayer, heating block, Chemidoc digital imager.

Assays - Clinical Trial Support

Immunohistochemistry and in-situ hybridisation (RNAScope).
Proliferation assays (T-cell response to immune therapy and vaccines).
Cytokine quantification using luminex (various panels but principally 27 plex from BioRad).
Minimal Residual Disease (MRD) by FACS analysis.
P53 codon 31 SNP analysis (in CLL) by FACS.
Real Time PCR analysis.
Limiting dilution NGS analysis of Tp53 (for CTC detection and analysis).

Validated Assays

CK18
M30/M65
NEFA
Cytokine Panel (27)
Creatinine
KIM-1
T cell proliferation
hENT-1
MRD

Please contact the GCPLab Programme Manager for further information.

Sample Collection

Tissue banking activity: Pancreas Cancer Biobank, UK Chronic Lymphocytic Leukaemia (CLL) Trials Biobank, Clatterbridge Cancer Centre (CCC) Biobank.
Centre contacts responsible for sample collection: Pancreas Cancer Biobank (Prof. Bill Greenhalf), UK CLL Trials Biobank (Dr Mel Oates), CCC Biobank (Dr Maria Maguire).

Further Information

If you require any information which isn't on the website please contact the Liverpool ECMC Team via e-mail.

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