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Title

HOPON: Hyperbaric Oxygen for the Prevention of Osteoradionecrosis.


Basic Trial Information

Phase Type Status Age Sponsor Protocol IDs Recruitment
III Treatment Open Over 18 University of Liverpool and Aintree University Hospital NHS Foundation trust EUDRACT No: 2007-006225-27
ISRCTN No: 39634732		 91

Purpose

One complication of radiotherapy for head and neck cancer is osteoradionecrosis (ORN) of the jaws. Osteoradionecrosis (ORN) describes the process where irradiated bone undergoes necrosis and becomes exposed through the investing soft tissues for a period of at least 3 months. The most important risk factor for ORN is surgical trauma, commonly dental extractions in an irradiated jaw, but ORN can also occur spontaneously. ORN is painful and debilitating, sometimes requiring surgical resection of the jaw and/or hyperbaric oxygen (HBO) treatments. The morbidity and mortality of osteoradionecrosis is significant and treatment outcomes often unsatisfactory.


Trial Lead Organisations

  • University Hospital Aintree NHS Foundation Trust
  • University of Liverpool
  • Chief Investigator: Mr Richard Shaw


Official Title

HOPON: Hyperbaric Oxygen for the Prevention of Osteoradionecrosis.


Trial Start Date

16/09/2008


References


Trial Coordinator

Matthew Bickerstaff


Trial Coordinator Email Address

oasis@liverpool.ac.uk


Trial Coordinator Contact No

0151 794 8934


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