Clinical Trials > Head and Neck > HOPON >> Information


HOPON: Hyperbaric Oxygen for the Prevention of Osteoradionecrosis.

Basic Trial Information

Phase Type Status Age Sponsor Protocol IDs Recruitment
III Treatment Open Over 18 University of Liverpool and Aintree University Hospitals NHS Foundation trust EUDRACT No: 2007-006225-27
ISRCTN No: 39634732


One complication of radiotherapy for head and neck cancer is osteoradionecrosis (ORN) of the jaws. Osteoradionecrosis (ORN) describes the process where irradiated bone undergoes necrosis and becomes exposed through the investing soft tissues for a period of at least 3 months. The most important risk factor for ORN is surgical trauma, commonly dental extractions in an irradiated jaw, but ORN can also occur spontaneously. ORN is painful and debilitating, sometimes requiring surgical resection of the jaw and/or hyperbaric oxygen (HBO) treatments. The morbidity and mortality of osteoradionecrosis is significant and treatment outcomes often unsatisfactory.

Trial Lead Organisations

  • University Hospital Aintree NHS Foundation Trust
  • University of Liverpool
  • Chief Investigator: Mr Richard Shaw

Official Title

HOPON: Hyperbaric Oxygen for the Prevention of Osteoradionecrosis.

Trial Start Date



Trial Coordinator

Matthew Bickerstaff

Trial Coordinator Email Address

Trial Coordinator Contact No

0151 794 8934

Admin/Site Area

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"The experience and treatment I received at the Royal Liverpool Hospital was so fantastic that I had to tell the people involved with my treatment how marvelous they were, so please would you pass on my thanks and gratitude to Professor Neoptolemos and his team of surgeons, the wonderful doctors and nursing staff" - Anon (Participant in ESPAC-3(v2) trial)

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